Article

A spatialised agent-based model of NOTCH signalling pathway in Endothelial Cells predicts emergent heterogeneity due to continual dynamic phenotypic adjustments

2022-08-06

Abstract excerpt

Vascular Endothelial Cells (EC) plasticity is key to homeostasis and its disruption is a hallmark of diseases such as cancer, atherosclerosis, and diabetes. The EC lineage has evolved to address in parallel sensor and actuator functions. This ability is reflected in remarkable phenotypical heterogeneity of EC across different tissues, within the same tissue, and within the same vascular bed as demonstrated by sing...

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Literature Corpus work: ed1d5ce9-857e-5831-9903-292188769b97
DOI: 10.1101/2022.08.06.503043

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