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Article

Jagged-Delta asymmetry in Notch signaling can give rise to a Sender/Receiver hybrid phenotype.

Proceedings of the National Academy of Sciences of the United States of America - 3 Feb 2015

Boareto Marcelo, Jolly Mohit Kumar, Lu Mingyang, Onuchic José N, Clementi Cecilia, Ben-Jacob Eshel

Abstract excerpt

Notch signaling pathway mediates cell-fate determination during embryonic development, wound healing, and tumorigenesis. This pathway is activated when the ligand Delta or the ligand Jagged of one cell interacts with the Notch receptor of its neighboring cell, releasing the Notch Intracellular Domain (NICD) that activates many downstream target genes. NICD affects ligand production asymmetrically--it represses...

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Identifiers

PMID: 25605936
DOI: 10.1073/pnas.1416287112
PMCID: PMC4321269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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