Article

Membrane compartmentalization by adherens junctions creates a spatial switch for Notch signaling and function

2021-11-04

Abstract excerpt

<title>Abstract</title> <p>Adherens junctions (AJs) create spatially and mechanically discrete microdomains at the interfaces of cells. Using a mechanogenetic platform that generates artificial AJs with controlled protein localization, clustering, and mechanical loading, we report that AJs also organize proteolytic hotspots for γ-secretase with a spatially-regulated substrate selectivity that is critical in the p...

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Literature Corpus work: 62ea08d9-b284-5611-b97c-d8000f10a42c
DOI: 10.21203/rs.3.rs-956506/v1

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