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Article

High-content image analysis to study phenotypic heterogeneity in endothelial cell monolayers.

Journal of cell science - 15 Jan 2022

Chesnais Francois, Hue Jonas, Roy Errin, Branco Marco, Stokes Ruby, Pellon Aize, Le Caillec Juliette, Elbahtety Eyad, Battilocchi Matteo, Danovi Davide, Veschini Lorenzo

Abstract excerpt

Endothelial cells (ECs) are heterogeneous across and within tissues, reflecting distinct, specialised functions. EC heterogeneity has been proposed to underpin EC plasticity independently from vessel microenvironments. However, heterogeneity driven by contact-dependent or short-range cell-cell crosstalk cannot be evaluated with single cell transcriptomic approaches, as spatial and contextual information is lost....

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PMID: 34982151
DOI: 10.1242/jcs.259104

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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