Article

TGF- Signaling Protects Retinal Neurons from Programmed Cell Death during the Development of the Mammalian Eye

2013-08-28

Abstract excerpt

We investigated the influence of transforming growth factor-β (TGF-β) signaling on developmental programmed cell death in the mouse retina by direct and specific molecular targeting of TGF-β type II receptor (TβRII) and Smad7 in retinal progenitor cells. Mice were generated carrying a conditional deletion of the TβRII in cells that originate from the inner layer of the optic cup. The animals showed a significant d...

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Literature Corpus work: ecf52aaa-a143-5673-8e00-cf3563901827
DOI: 10.1523/jneurosci.0991-13.2013

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