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Article

Inhibitory peptide of mitochondrial μ-calpain protects against photoreceptor degeneration in rhodopsin transgenic S334ter and P23H rats.

PloS one - 1 Jan 2013

Ozaki Taku, Ishiguro Sei-ichi, Hirano Satoshi, Baba Ayaka, Yamashita Tetsuro, Tomita Hiroshi, Nakazawa Mitsuru

Abstract excerpt

Mitochondrial μ-calpain and apoptosis-inducing factor (AIF)-dependent photoreceptor cell death has been seen in several rat and mouse models of retinitis pigmentosa (RP). Previously, we demonstrated that the specific peptide inhibitor of mitochondrial μ-calpain, Tat-µCL, protected against retinal degeneration following intravitreal injection or topical eye-drop application in Mertk gene-mutated Royal College of...

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Source

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Identifiers

PMID: 23951212
DOI: 10.1371/journal.pone.0071650
PMCID: PMC3739725

Genes

ERG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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