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Article

BMP signaling mediates stem/progenitor cell-induced retina regeneration

14 Dec 2007

Abstract excerpt

We identified a mechanism whereby retina regeneration in the embryonic chick can be induced by the contribution of stem/progenitor cells. We show that bone morphogenetic protein (BMP) signaling is sufficient and necessary to induce retina regeneration and that its action can be divided into two phases. By 3 days after postretinectomy (d PR), the BMP pathway directs proliferation and regeneration through the...

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PMID: 18093961
DOI: 10.1073/pnas.0708202104

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