Article
Temporally distinct patterns of p53-dependent and p53-independent apoptosis during mouse lens development.
Genes & development - 1 Sept 1995
Pan H, Griep A E
Abstract excerpt
Programmed cell death, or apoptosis, is a critical event in the development of multicellular organisms, and its perturbation is implicated in many diseases including cancer. The tumor suppressor protein p53 is known to mediate apoptosis induced by the DNA tumor virus oncoproteins, adenovirus E1A (AdE1A) and SV40 T antigen (SV40 Tag). We have recently demonstrated that the E6 and E7 oncoproteins of human...
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