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Article

Knockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment.

Cell death & disease - 15 Feb 2018

Cai Shijiao, Chen Yang, Shang Yue, Cui Jianlin, Li Zongjin, Li Yuhao

Abstract excerpt

Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted knockdown of il7r leads to delayed myelination, highlighting the potential role of il7r in the development of the nervous system. Zebrafish is an ideal model for the study of neurogenesis; moreover, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29449560
DOI: 10.1038/s41419-018-0337-z
PMCID: PMC5833684

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