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Smad4 is required predominantly in the developmental processes dependent on the BMP branch of the TGF-β signaling system in the embryonic mouse retina.

Investigative ophthalmology & visual science - 2 May 2011

Murali Deepa, Kawaguchi-Niida Motoko, Deng Chu-Xia, Furuta Yasuhide

Abstract excerpt

PURPOSE: The present study was aimed at defining developmental roles of Smad4, a key mediator of the TGF-β superfamily signaling system, in the embryonic mouse retina. METHODS: Using a Cre/loxP-mediated conditional gene targeting approach, Smad4 gene function was deleted from the embryonic mouse retina. Mutant phenotypes were morphologically and molecularly examined. RESULTS: Loss of Smad4 in the developing...

Topics

Animals
Apoptosis
Axons
Bone Morphogenetic Proteins
Female
Fluorescent Antibody Technique, Indirect
Gene Deletion
Gene Expression Regulation, Developmental
Genotype
In Situ Hybridization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

In Situ Nick-End Labeling

Male

Mice

Mice, Knockout

Microphthalmos

Polymerase Chain Reaction

Retina

Retinal Ganglion Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 21273545
DOI: 10.1167/iovs.10-5940
PMCID: PMC3109008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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