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Article

Retinal regeneration in adult zebrafish requires regulation of TGFβ signaling.

Glia - 1 Oct 2013

Lenkowski Jenny R, Qin Zhao, Sifuentes Christopher J, Thummel Ryan, Soto Celina M, Moens Cecilia B, Raymond Pamela A

Abstract excerpt

Müller glia are the resident radial glia in the vertebrate retina. The response of mammalian Müller glia to retinal damage often results in a glial scar and no functional replacement of lost neurons. Adult zebrafish Müller glia, in contrast, are considered tissue-specific stem cells that can self-renew and generate neurogenic progenitors to regenerate all retinal neurons after damage. Here, we demonstrate that...

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Identifiers

PMID: 23918319
DOI: 10.1002/glia.22549
PMCID: PMC4127981

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