Article

Identification of target genes and regulatory networks for bone mineral density GWAS loci through systematic targeting and inhibition

2026-02-16

Abstract excerpt

Osteoporosis is characterized by low bone mineral density (BMD) and elevated fracture risk. Most BMD-associated GWAS variants lie in noncoding regions, complicating efforts to identify causal genes and mechanisms. To overcome this variant-to-function challenge, we previously developed STING-seq, a framework integrating biobank-scale GWAS with single-cell CRISPR inhibition (CRISPRi) screening to directly connect no...

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Literature Corpus work: ece72050-f99c-540b-aa6c-a2d6d1975b9f
DOI: 10.64898/2026.02.11.705362

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