Article

An Atlas of Human and Murine Genetic Influences on Osteoporosis

2018-06-11

Abstract excerpt

Osteoporosis is a common debilitating chronic disease diagnosed primarily using bone mineral density (BMD). We undertook a comprehensive assessment of human genetic determinants of bone density in 426,824 individuals, identifying a total of 518 genome-wide significant loci, (301 novel), explaining 20% of the total variance in BMD—as estimated by heel quantitative ultrasound (eBMD). Next, meta-analysis identified 1...

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Literature Corpus work: b2927fe4-6ee3-5eeb-9d1f-226ecf86f2ca
DOI: 10.1101/338863

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