Article

GWAS-Informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density

2024-03-20

Abstract excerpt

<h4>ABSTRACT</h4> Over 1,100 independent signals have been identified with genome-wide association studies (GWAS) for bone mineral density (BMD), a key risk factor for mortality-increasing fragility fractures; however, the effector gene(s) for most remain unknown. Informed by a variant-to-gene mapping strategy implicating 89 non-coding elements predicted to regulate osteoblast gene expression at BMD GWAS loci, we...

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Literature Corpus work: aae4da1e-3577-5d8b-8c43-c87e47014426
DOI: 10.1101/2024.03.19.585778

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