Article
Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual.
Genome biology - 4 Jan 2021
Cousminer Diana L, Wagley Yadav, Pippin James A, Elhakeem Ahmed, Way Gregory P, Pahl Matthew C, McCormack Shana E, Chesi Alessandra, Mitchell Jonathan A, Kindler Joseph M, Baird Denis, Hartley April, Howe Laura, Kalkwarf Heidi J, Lappe Joan M, Lu Sumei, Leonard Michelle E, Johnson Matthew E, Hakonarson Hakon, Gilsanz Vicente, Shepherd John A, Oberfield Sharon E, Greene Casey S, Kelly Andrea, Lawlor Deborah A, Voight Benjamin F, Wells Andrew D, Zemel Babette S, Hankenson Kurt D, Grant Struan F A
Abstract excerpt
BACKGROUND: Bone accrual impacts lifelong skeletal health, but genetic discovery has been primarily limited to cross-sectional study designs and hampered by uncertainty about target effector genes. Here, we capture this dynamic phenotype by modeling longitudinal bone accrual across 11,000 bone scans in a cohort of healthy children and adolescents, followed by genome-wide association studies (GWAS) and...
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