Article

Single-cell Transcriptomics Identifies Gene Expression Networks Driving Differentiation and Tumorigenesis in the Human Fallopian Tube

2020-05-30

Abstract excerpt

<h4>Summary</h4> The human fallopian tube harbors the cell-of-origin for the majority of high-grade serous ‘ovarian’ cancers (HGSCs), but its cellular composition, particularly the epithelial component, is poorly characterized. We performed single-cell transcriptomic profiling in 12 primary fallopian specimens from 8 patients, analyzing around 53,000 individual cells to map the major immune, fibroblastic and epit...

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Literature Corpus work: cd98d2c0-4bce-5451-b151-565dd867d491
DOI: 10.1101/2020.05.28.119933

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