Article

EGFR signaling and pharmacology in oncology revealed with innovative BRET-based biosensors

2023-06-30

Abstract excerpt

<title>Abstract</title> <p>Dysregulation of receptor tyrosine kinases (RTKs) is associated with the development of many cancers. Intrinsic and acquired mutations of RTKs modify receptor signaling contributing to drug resistance in clinical settings. We present enhanced bystander bioluminescence resonance energy transfer-based biosensors providing new insights into RTK biology and pharmacology critical for the dev...

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Literature Corpus work: 79bb44f4-256e-592c-b479-2c32fa18f243
DOI: 10.21203/rs.3.rs-2981812/v1

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