Article

BRAF <sup>V600E</sup> -Driven Lung Tumorigenesis Requires Ligand-Mediated Activation of ERBB Receptor Signaling

2025-05-09

Abstract excerpt

<h4>ABSTRACT</h4> Secretion of ligands of the human epidermal growth factor (EGFR) family of receptors or erythroblastic leukemia viral oncogene family (ERBB1-4) is a feature common to many cancer cells. However, our understanding of the role of autocrine ligands in the aberrant behavior of cancer remains incomplete. Here we demonstrate that, in numerous preclinical models of lung tumorigenesis, BRAF V600E signa...

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Literature Corpus work: 2cd66c24-fef4-58c3-8900-9c2c76f56069
DOI: 10.1101/2025.05.04.652129

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