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Article

The Measurement of Receptor Signaling Bias.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2015

Kenakin Terry

Abstract excerpt

This chapter describes a method to quantify biased signaling effects of agonists; this approach can furnish a scale for medicinal chemists to optimize biased profiles. Biased ligands have different pharmacological properties on a molecular level (stabilization of different receptor active states) and thus can have different pharmacological profiles therapeutically. The calculation of transduction ratios...

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PMID: 26260600
DOI: 10.1007/978-1-4939-2914-6_11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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