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Targeting the 8-oxodG Base Excision Repair Pathway for Cancer Therapy

14 Jan 2025

Abstract excerpt

Genomic integrity is critical for cellular homeostasis, preventing the accumulation of mutations that can drive diseases such as cancer. Among the mechanisms safeguarding genomic stability, the Base Excision Repair (BER) pathway plays a pivotal role in counteracting oxidative DNA damage caused by reactive oxygen species. Central to this pathway are enzymes like 8-oxoguanine glycosylase 1 (OGG1), which recognize...

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Cancer therapeutics and mechanisms
DNA Repair Mechanisms
PARP inhibition in cancer therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39851540
DOI: 10.3390/cells14020112

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