Article

OGG1-Binding to Oxidized Guanine Base in Viral DNA Overcomes Epstein–Barr Virus Latency

2026-06-06

Abstract excerpt

Epstein–Barr virus (EBV) establishes lifelong latency in human cells and can periodically reactivate, contributing to several cancers. However, the molecular mechanisms that disrupt EBV latency, particularly those driven by oxidative stress, require further investigation. In this study, we provide evidence that oxidative DNA damage, particularly the formation of 8-oxoguanine and its repair enzyme OGG1, is involved...

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Literature Corpus work: a7864647-157a-57c5-a283-cee608a53554
DOI: 10.64898/2026.06.05.728896

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