Article

Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humans

2025-05-27

Abstract excerpt

<h4>ABSTRACT</h4> Mass effect, characterized by the compression and deformation of neural tissue from space-occupying lesions, can lead to debilitating neurological symptoms and poses a significant clinical challenge. In the primary brain tumor glioblastoma (GBM), we have shown previously that compressive solid stress originating from the growing tumor reduces cerebral blood flow, leads to neuronal loss, increase...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ecae3419-b9a8-5a08-91ae-bcc950ba1fa8
DOI: 10.1101/2025.05.22.655651

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humansDOI 10.1101/2025.05.22.655651Read

Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injurySemantic proximity Read

Chronic compression drives macrophages toward a pathological pro-tumor stateSemantic proximity Read

Chronic compression induces transcriptional, metabolic, and functional state changes in macrophages that recapitulate tumor-associated phenotypes.Semantic proximity Read

Compression force promotes glioblastoma progression through the Piezo1‑GDF15‑CTLA4 axisSemantic proximity Read

From Traumatic Brain Injury to Alzheimer’s Disease: Multilevel Biomechanical, Neurovascular and Molecular Mechanisms with Emerging Therapeutic DirectionsSemantic proximity Read

Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain ParenchymaSemantic proximity Read

Fluid shear stress on astrocytes and microglia promotes neuronal toxicity <i>in vitro</i> via purinergic signalingSemantic proximity Read

Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes.Semantic proximity Read

Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome AnalysisSemantic proximity Read

Concussion pathophysiology: From biomechanical insult to clinical phenotype - or is injury truly the beginning?Semantic proximity Read

Intratumoral Heterogeneity of Vimentin Modulates Nuclear Mechanotransduction, DNA Damage Response and Cancer Cell SurvivalSemantic proximity Read

Human cranial bone-derived mesenchymal stem cells cultured under microgravity can improve cerebral infarction in ratsSemantic proximity Read