Article

Fluid shear stress on astrocytes and microglia promotes neuronal toxicity <i>in vitro</i> via purinergic signaling

2025-05-03

Abstract excerpt

Interstitial fluid flow plays a critical role in maintaining function and homeostasis in neural tissue, and dysregulation of this flow due to injury or disease results in mechanical stress that is associated with several neuropathologies, including traumatic brain injury, ischemic stroke, and glioma. Glial cells such as astrocytes and microglia are known to respond to mechanical forces like fluid shear stress but...

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Literature Corpus work: 7770a04e-6cf7-51bf-acf1-72fee299f081
DOI: 10.1101/2025.04.29.651240

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