Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injury

2 Aug 2016

Abstract excerpt

In the United States over 1.7 million cases of traumatic brain injury are reported yearly, but predictive correlation of cellular injury to impact tissue strain is still lacking, particularly for neuronal injury resulting from compression. Given the prevalence of compressive deformations in most blunt head trauma, this information is critically important for the development of future mitigation and diagnosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Traumatic Brain Injury and Neurovascular Disturbances
Share to Traumatic Brain Injury Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27480807
DOI: 10.1038/srep30550

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Strain and rate-dependent neuronal injury in a 3D in vitro compression model of traumatic brain injuryPMID 27480807Read ↗

Mechanical compression induces neuronal apoptosis, reduces synaptic activity, and promotes glial neuroinflammation in mice and humansSemantic proximity Read ↗

Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes.Semantic proximity Read ↗

Mechanical stretch disrupts calcium dynamics and redistributes Piezo1 in human astrocytesSemantic proximity Read ↗

From Traumatic Brain Injury to Alzheimer’s Disease: Multilevel Biomechanical, Neurovascular and Molecular Mechanisms with Emerging Therapeutic DirectionsSemantic proximity Read ↗

Craniocerebral trauma: protection and retrieval of the neuronal population after injury.Semantic proximity Read ↗

Differences between two maximal principal strain rate calculation schemes in traumatic brain analysis with in-vivo and in-silico datasetsSemantic proximity Read ↗

Brain strain rate response: addressing computational ambiguity and experimental data for model validationSemantic proximity Read ↗

An in vitro injury model for SH-SY5Y neuroblastoma cells: Effect of strain and strain rateSemantic proximity Read ↗

Concussion pathophysiology: From biomechanical insult to clinical phenotype - or is injury truly the beginning?Semantic proximity Read ↗

In silico investigation of biomechanical response of a human subjected to primary blastSemantic proximity Read ↗

Injury-induced CTE-like pathology emerges in a human multicellular <i>in vitro</i> brain model and reveals mitochondrial and neurovascular regulationSemantic proximity Read ↗

A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize with MAPT Mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.