Article

Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome Analysis

2022-12-09

Abstract excerpt

Central nervous system (CNS) diseases, such as neurodegenerative disorders and brain diseases caused by acute injuries, are important yet challenging to study due to disease leisions’ locations and other complexities. Utilizing the powerful spatial transcriptome analysis together with novel algorithms we developed for the study, we report here for the first time a 3D trajectory map of gene expression changes in th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a70d9408-72b7-56bf-b712-6ed5f8764301
DOI: 10.1101/2022.12.06.519018

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Discovering Haematoma-Stimulated Circuits for Secondary Brain Injury after Intraventricular Haemorrhage by Spatial Transcriptome AnalysisDOI 10.1101/2022.12.06.519018Read

Spatiotemporal transcriptomic maps of mouse intracerebral hemorrhage at single-cell resolutionSemantic proximity Read

MyD88-TLR4-dependent choroid plexus activation precedes perilesional inflammation and edema in intracerebral hemorrhageSemantic proximity Read

Bioinformatics Analysis Identifies Potential Ferroptosis Key Genes in the Pathogenesis of Intracerebral HemorrhageSemantic proximity Read

Molecular Correlates of Hemorrhage and Edema Volumes Following Human Intracerebral Hemorrhage Implicate Inflammation, Autophagy, mRNA Splicing, and T Cell Receptor SignalingSemantic proximity Read

Single-cell RNA-seq reveals changes in cell subsets in the intraperitoneal lavage fluid during severe heat stroke miceSemantic proximity Read

Single-cell RNA sequencing reveals the evolution of the immune landscape during perihematomal edema progression after intracerebral hemorrhageSemantic proximity Read

Single-Cell Profiling Resolved Transcriptional Alterations and Lineage Dynamics of Subventricular Zone after Mild Traumatic Brain InjurySemantic proximity Read

Spatiotemporal heterogeneity and protective polarization of astrocytes depending on intercellular interaction after intracerebral hemorrhageSemantic proximity Read

A spatiotemporal immune atlas of subarachnoid hemorrhage from single-cell and spatial transcriptomicsSemantic proximity Read

Injury-induced CTE-like pathology emerges in a human multicellular <i>in vitro</i> brain model and reveals mitochondrial and neurovascular regulationSemantic proximity Read

The Landscape of Gene Expression and Molecular Regulation Following Spinal Cord Hemisection in RatsSemantic proximity Read

Spatiotemporal transcriptome analysis reveals that conversion of IKFZ1-mediated microglia underlies a therapy for intracerebral hemorrhageSemantic proximity Read