Article

Chronic compression drives macrophages toward a pathological pro-tumor state

2025-05-17

Abstract excerpt

Macrophages comprise a significant portion of the glioblastoma tumor microenvironment and are essential in promoting immunosuppression and tumor progression. Solid tumors such as glioblastoma generate solid stress as they expand, creating a compressive microenvironment for mechanosensitive immune cells including macrophages. Macrophages are known to respond to various mechanical stimuli but have not yet been studi...

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Literature Corpus work: 8122dda7-1e80-5648-980f-69c56653c9ce
DOI: 10.1101/2025.05.13.653793

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