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Concussion pathophysiology: From biomechanical insult to clinical phenotype - or is injury truly the beginning?

Seminars in pediatric neurology - 1 Jul 2026

Khambadkone Seva G, Piantino Juan A

Abstract excerpt

Mild traumatic brain injury (mTBI) is associated with substantial morbidity worldwide. Emerging evidence demonstrates that both impact- and blast-related mTBI produce diffuse microstructural and functional alterations, e.g., diffuse axonal injury, astroglial and microglial activation, cerebrovascular dysfunction, and neurometabolic disturbance. Rotational acceleration in impact injury preferentially induces white...

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PMID: 42264871
DOI: 10.1016/j.spen.2026.101266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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