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Article

Biofidelic dynamic compression of human cortical spheroids reproduces neurotrauma phenotypes.

Disease models & mechanisms - 1 Dec 2021

Shoemaker Aaron R, Jones Ian E, Jeffris Kira D, Gabrielli Gina, Togliatti Alyssa G, Pichika Rajeswari, Martin Eric, Kiskinis Evangelos, Franz Colin K, Finan John D

Abstract excerpt

Fundamental questions about patient heterogeneity and human-specific pathophysiology currently obstruct progress towards a therapy for traumatic brain injury (TBI). Human in vitro models have the potential to address these questions. Three-dimensional spheroidal cell culture protocols for human-origin neural cells have several important advantages over their two-dimensional monolayer counterparts....

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Identifiers

PMID: 34746950
DOI: 10.1242/dmm.048916
PMCID: PMC8713991

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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