Article

High-Throughput 5’ UTR Engineering for Enhanced Protein Production in Non-Viral Gene Therapies

2020-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Despite significant clinical progress in cell and gene therapies, maximizing protein expression in order to enhance potency remains a major challenge. One approach to increase protein expression is by optimizing translation through the engineering of 5’ untranslated regions (5’ UTRs). Here, we developed a high-throughput strategy to design, screen, and optimize novel 5’UTRs that enhance protein...

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Literature Corpus work: ec98daba-7c12-5889-8fd2-dc7af4e189c8
DOI: 10.1101/2020.03.24.006486

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