Article

Inflammation and bacteriophages affect DNA inversion states and functionality of the gut microbiota

2023-04-01

Abstract excerpt

<h4>Summary</h4> Reversible genomic DNA-inversions control expression of numerous bacterial molecules in the human gut, but how this relates to disease remains uncertain. By analyzing metagenomic samples from six human Inflammatory Bowel Disease cohorts combined with mice experimentation, we identified multiple invertible regions where a particular orientation was correlated with disease. These include the promot...

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Literature Corpus work: ec7dcc02-0d6a-5744-8fe7-14b692ab3680
DOI: 10.1101/2023.03.31.535104

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