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Plasmids in the human gut reveal neutral dispersal and recombination that is overpowered by inflammatory diseases

11 Apr 2024

Abstract excerpt

Plasmids are pivotal in driving bacterial evolution through horizontal gene transfer. Here, we investigated 3467 human gut microbiome samples across continents and disease states, analyzing 11,086 plasmids. Our analyses reveal that plasmid dispersal is predominantly stochastic, indicating neutral processes as the primary driver of their wide distribution. We find that only 20-25% of plasmid DNA is being selected...

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PMID: 38605009
DOI: 10.1038/s41467-024-47272-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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