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Article

Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation.

Science immunology - 8 Apr 2022

Adiliaghdam Fatemeh, Amatullah Hajera, Digumarthi Sreehaas, Saunders Tahnee L, Rahman Raza-Ur, Wong Lai Ping, Sadreyev Ruslan, Droit Lindsay, Paquette Jean, Goyette Philippe, Rioux John D, Hodin Richard, Mihindukulasuriya Kathie A, Handley Scott A, Jeffrey Kate L

Abstract excerpt

Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic viruses and bacteriophages (collectively, the virome), enriched from non-IBD, noninflamed human colon resections, actively elicited atypical anti-inflammatory innate immune programs. Conversely, ulcerative colitis or Crohn's...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 35394816
DOI: 10.1126/sciimmunol.abn6660
PMCID: PMC9416881

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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