Article

Generation of an inducible destabilized-domain Cre mouse line to target disease associated microglia

2024-09-19

Abstract excerpt

<h4>Summary</h4> The function of microglia during progression of Alzheimer’s disease (AD) can be investigated using mouse models that enable genetic manipulation of microglial subpopulations in a temporal manner. We developed a mouse strain that expresses destabilized-domain Cre recombinase (DD-Cre) from the Cst7 locus ( Cst7 DD-Cre ) and tested this in 5xFAD amyloidogenic, Ai14 tdTomato cre-reporter line mice....

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Literature Corpus work: ec5f21d2-52ae-5b96-9a65-8bef8206c7a3
DOI: 10.1101/2024.09.18.613773

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