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Article

Phospho-mimic βIII-tubulin rescues microtubule and cardiac defects in Duchenne muscular dystrophy mice.

Journal of molecular and cellular cardiology - 1 Jun 2026

Zhou Delong, Nouet Julie, Mesa Elam, Yegneshwaran Vasisht, Geukgeuzian Geovanni, Adibemma Ifeanyichukwu D, Ramirez Edwin, Ali Nehal Kamal, Hilfiker Sabine, Li Hong, Liu Tong, Yehia Ghassan, Romanienko Peter J, Rodney George G, Wehrens Xander H T, Lampe Paul D, Gourdie Robert G, Xie Lai-Hua, Fraidenraich Diego

Abstract excerpt

Duchenne muscular dystrophy (DMD) cardiomyopathy is caused by mutations in the dystrophin gene and characterized by profound cytoskeletal disorganization, particularly pathological remodeling of the cardiomyocyte microtubule network. While the role of dystrophin in maintaining sarcolemmal integrity is well-established, its specific association with microtubule dynamics through post-translational modifications...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42001993
DOI: 10.1016/j.yjmcc.2026.04.004
PMCID: PMC13227544

Genes

DMD

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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