Article

Microtubule detyrosination alters nuclear mechanotransduction and leads to pro-hypertrophic signaling in hypertrophic cardiomyopathy

2025-04-02

Abstract excerpt

<h4>Background</h4> Hypertrophic cardiomyopathy (HCM) is characterized by left ventricular hypertrophy and diastolic dysfunction and is accompanied by extensive cytoskeletal remodeling, including increased protein levels of desmin, tubulin and detyrosinated tubulin. We have previously demonstrated that tubulin detyrosination contributes to diastolic dysfunction. Microtubules are connected to the nucleus by the LI...

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Literature Corpus work: 663f4060-23c1-58ab-9250-8aa3f2d26a5c
DOI: 10.1101/2025.03.28.646061

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