Article

Matrix Stiffening Induces Mechanical Memory and Nuclear Fragility in Cardiomyocytes via Microtubule-Lamin Coupling

2025-07-21

Abstract excerpt

<h4>Background</h4> Mechanical memory (MM) describes the persistent phenotypic remodeling following exposure to a transient extrinsic biomechanical cue. Short-term biomechanical stress is a feature of several etiologies of cardiomyopathy, including dysfunction of the viable myocardium following a large myocardial infarction. However, the nuclear mechanisms linking stiffness to persistent cellular remodeling remai...

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Literature Corpus work: 5acf12c1-a36c-5475-b38c-b2571a9ed00b
DOI: 10.1101/2025.07.17.665449

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