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Article

RBM20S639G mutation is a high genetic risk factor for premature death through RNA-protein condensates.

Journal of molecular and cellular cardiology - 1 Apr 2022

Wang Chunyan, Zhang Yanghai, Methawasin Mei, Braz Camila Urbano, Gao-Hu Jeffrey, Yang Betty, Strom Joshua, Gohlke Jochen, Hacker Timothy, Khatib Hasan, Granzier Henk, Guo Wei

Abstract excerpt

Dilated cardiomyopathy (DCM) is a heritable and genetically heterogenous disease often idiopathic and a leading cause of heart failure with high morbidity and mortality. DCM caused by RNA binding motif protein 20 (RBM20) mutations is diverse and needs a more complete mechanistic understanding. RBM20 mutation S637G (S639G in mice) is linked to severe DCM and early death in human patients. In this study, we...

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Identifiers

PMID: 35041844
DOI: 10.1016/j.yjmcc.2022.01.004
PMCID: PMC8940686

Genes

RBM20

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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