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Article

Depletion of Vasohibin 1 Speeds Contraction and Relaxation in Failing Human Cardiomyocytes.

Circulation research - 3 Jul 2020

Chen Christina Yingxian, Salomon Alexander K, Caporizzo Matthew A, Curry Sam, Kelly Neil A, Bedi Kenneth, Bogush Alexey I, Krämer Elisabeth, Schlossarek Saskia, Janiak Philip, Moutin Marie-Jo, Carrier Lucie, Margulies Kenneth B, Prosser Benjamin L

Abstract excerpt

RATIONALE: Impaired myocardial relaxation is an intractable feature of several heart failure (HF) causes. In human HF, detyrosinated microtubules stiffen cardiomyocytes and impair relaxation. Yet the identity of detyrosinating enzymes have remained ambiguous, hindering mechanistic study and therapeutic development. OBJECTIVE: We aimed to determine if the recently identified complex of VASH1/2 (vasohibin 1/2) and...

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Identifiers

PMID: 32272864
DOI: 10.1161/CIRCRESAHA.119.315947
PMCID: PMC7334093

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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