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Protein Quality Control Activation and Microtubule Remodeling in Hypertrophic Cardiomyopathy

18 Jul 2019

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac disorder. It is mainly caused by mutations in genes encoding sarcomere proteins. Mutant forms of these highly abundant proteins likely stress the protein quality control (PQC) system of cardiomyocytes. The PQC system, together with a functional microtubule network, maintains proteostasis. We compared left ventricular (LV) tissue of nine donors...

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PMID: 31323898
DOI: 10.3390/cells8070741

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