Article

Dynamic remodeling of the pancreas immune landscape in obesity

2025-08-27

Abstract excerpt

<title>Abstract</title> <p>Obesity is a known risk factor for diseases of the pancreas, including diabetes, pancreatic cancer and pancreatitis, but mechanisms remain unclear. To elucidate how obesity impacts pancreatic immune homeostasis, we performed spatial, transcriptomic and functional profiling of human pancreatic immune cells from obese and non-obese organ donors. Obesity was associated with higher density...

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Literature Corpus work: 8ac439ee-a2a2-50fb-8d74-ef5d6aba079c
DOI: 10.21203/rs.3.rs-7123997/v1

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