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Article

Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization.

Journal of leukocyte biology - 1 Jan 2014

Cucak Helena, Grunnet Lars Groth, Rosendahl Alexander

Abstract excerpt

Human T2D is characterized by a low-grade systemic inflammation, loss of β-cells, and diminished insulin production. Local islet immunity is still poorly understood, and hence, we evaluated macrophage subpopulations in pancreatic islets in the well-established murine model of T2D, the db/db mouse. Already at 8 weeks of disease, on average, 12 macrophages were observed in the diabetic islets, whereas only two were...

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Identifiers

PMID: 24009176
DOI: 10.1189/jlb.0213075

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