Article

Comprehensive annotation of 3′UTRs from primary cells and their quantification from scRNA-seq data

2021-11-23

Abstract excerpt

Approximately half of human genes generate mRNA isoforms that differ in their 3′UTRs while encoding the same protein. 3′UTR and mRNA length is determined by 3′ end cleavage sites (CS). Here, we mapped and categorized mRNA 3′ end CS in more than 200 primary human and mouse cell types, resulting in a 40% increase of CS annotations relative to the GENCODE database. We incorporated these annotations into a novel compu...

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Literature Corpus work: ec41d1fd-fb94-5569-9c1a-7d565e0d6dda
DOI: 10.1101/2021.11.22.469635

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