Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration.

Neuron - 20 Apr 2022

LaForce Geneva R, Farr Jordan S, Liu Jingyi, Akesson Cydni, Gumus Evren, Pinkard Otis, Miranda Helen C, Johnson Katherine, Sweet Thomas J, Ji Ping, Lin Ai, Coller Jeff, Philippidou Polyxeni, Wagner Eric J, Schaffer Ashleigh E

Abstract excerpt

Tight regulation of mRNA isoform expression is essential for neuronal development, maintenance, and function; however, the repertoire of proteins that govern isoform composition and abundance remains incomplete. Here, we show that the RNA kinase CLP1 regulates mRNA isoform expression through suppression of proximal cleavage and polyadenylation. We found that human stem-cell-derived motor neurons without CLP1 or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mutation
Share to Neurodegenerative Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Polyadenylation

Share to RNA Isoforms

Share to RNA, Messenger

Share to RNA modifications and cancer

Share to RNA Research and Splicing

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 35139363
DOI: 10.1016/j.neuron.2022.01.018
PMCID: PMC9035109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of premature transcription termination leads to reduced mRNA isoform diversity and neurodegeneration.PMID 35139363Read ↗

Comprehensive annotation of 3′UTRs from primary cells and their quantification from scRNA-seq dataSemantic proximity Read ↗

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanismsSemantic proximity Read ↗

The diversity of <i>SNCA</i> transcripts in neurons, and its impact on antisense oligonucleotide therapeuticsSemantic proximity Read ↗

The Clp1 R140H mutation alters tRNA metabolism and mRNA 3' processing in mouse models of pontocerebellar hypoplasia.Semantic proximity Read ↗

Poison exons in neurodevelopment and disease.Semantic proximity Read ↗

SNAPC4-related neurodevelopmental disorder defines a stage-dependent spliceosomopathy with heterogeneous clinical trajectoriesSemantic proximity Read ↗

Long-Read RNA-sequencing reveals transcript-specific regulation in human-derived cortical neuronsSemantic proximity Read ↗

Aberrant RNA processing events in neurological disordersSemantic proximity Read ↗

Cell-specific RNA isoform remodeling in the aging mouse brainSemantic proximity Read ↗

A compendium of conserved cleavage and polyadenylation events in mammalian genes.Semantic proximity Read ↗

Variants in SCAF4 Cause a Neurodevelopmental Disorder and Are Associated with Impaired mRNA Processing.Semantic proximity Read ↗

Genetic and functional analysis of unproductive splicing using LeafCutter2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.