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Article

Analysis of ligand binding and resulting conformational changes in pyrophosphatase NUDT9.

The FEBS journal - 1 Dec 2021

Gattkowski Ellen, Rutherford Trevor J, Möckl Franziska, Bauche Andreas, Sander Simon, Fliegert Ralf, Tidow Henning

Abstract excerpt

Nudix hydrolase 9 (NUDT9) is a member of the nucleoside linked to another moiety X (NUDIX) protein superfamily, which hydrolyses a broad spectrum of organic pyrophosphates from metabolic processes. ADP-ribose (ADPR) has been the only known endogenous substrate accepted by NUDT9 so far. The Ca2+ -permeable transient receptor potential melastatin subfamily 2 (TRPM2) channel contains a homologous NUDT9-homology...

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Share to Adenosine Diphosphate Ribose
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34189846
DOI: 10.1111/febs.16097
PMCID: PMC7612441

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