Article

Stromal LOX–FAK–β-catenin pathway locks mammary fibroblasts into a tumor-promoting myCAF state

2025-07-17

Abstract excerpt

<h4>Background</h4> Cancer-associated fibroblasts (CAFs) sustain tumor progression, yet the soluble cues that maintain their myofibroblast (myCAF) state are poorly defined. Transforming growth factor beta (TGF-β) is a canonical CAF activator. This study aims to identify TGF-β-induced secreted mediators that reinforce the myCAF phenotype in breast cancer and map the downstream signaling cascade. <h4>Methods and Re...

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Literature Corpus work: ec255421-c1b2-5f04-9209-e913f00afb18
DOI: 10.1101/2025.07.11.664481

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