Article

MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer- associated fibroblasts

2025-02-24

Abstract excerpt

<title>Abstract</title> Breast cancer-associated fibroblasts (bCAFs) comprise inflammatory CAFs (iCAFs), characterized by the secretion of pro-inflammatory cytokines, and myofibroblastic CAFs (myCAFs), distinguished by their high production of extracellular matrix and their immunosuppressive properties. We previously showed that targeting the anti-apoptotic protein MCL-1 in primary culture of bCAF derived dire...

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Literature Corpus work: c6b236ad-bfbb-5b86-9db0-e0328325d7fd
DOI: 10.21203/rs.3.rs-6007010/v1

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