Article

Unraveling the YAP1-TGFb1 axis: a key driver of androgen receptor loss in prostate cancer-associated fibroblasts

2025-03-14

Abstract excerpt

<title>Abstract</title> <p> Due to their pivotal roles in tumor progression and therapy resistance, cancer-associated fibroblasts (CAF) are considered key therapeutic targets with loss of stromal androgen receptor (AR) a poorly understood hallmark of aggressive prostate cancer (PCa). A paucity of pre-clinical models however has hampered functional studies of CAF heterogeneity. <bold/> We demonstrate that our n...

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Literature Corpus work: af99304b-f703-5278-9cc9-bf1304150eab
DOI: 10.21203/rs.3.rs-3258823/v2

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