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Article

Role of oxidative stress and the microenvironment in breast cancer development and progression.

Advances in cancer research - 1 Jan 2013

Jezierska-Drutel Agnieszka, Rosenzweig Steven A, Neumann Carola A

Abstract excerpt

Breast cancer is a highly complex tissue composed of neoplastic and stromal cells. Carcinoma-associated fibroblasts (CAFs) are commonly found in the cancer stroma, where they promote tumor growth and enhance vascularity in the microenvironment. Upon exposure to oxidative stress, fibroblasts undergo activation to become myofibroblasts. These cells are highly mobile and contractile and often express numerous...

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Identifiers

PMID: 23870510
DOI: 10.1016/B978-0-12-407190-2.00003-4
PMCID: PMC3950899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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