Article

MCL-1 as a molecular switch between myofibroblastic and pro-angiogenic features of breast cancer-associated fibroblasts

2025-02-15

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer-associated fibroblasts (bCAFs) comprise inflammatory CAFs (iCAFs), characterized by the secretion of pro-inflammatory cytokines, and myofibroblastic CAFs (myCAFs), distinguished by their high production of extracellular matrix and their immunosuppressive properties. We previously showed that targeting the anti-apoptotic protein MCL-1 in primary culture of bCAF derived directly from...

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Literature Corpus work: 35e9d036-730b-56ae-961c-5c2880fa90aa
DOI: 10.1101/2025.02.10.637434

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