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Article

Breast Cancer CAFs: Spectrum of Phenotypes and Promising Targeting Avenues.

International journal of molecular sciences - 27 Oct 2021

Elwakeel Eiman, Weigert Andreas

Abstract excerpt

Activationof the tumor-associated stroma to support tumor growth is a common feature observed in different cancer entities. This principle is exemplified by cancer-associated fibroblasts (CAFs), which are educated by the tumor to shape its development across all stages. CAFs can alter the extracellular matrix (ECM) and secrete a variety of different molecules. In that manner they have the capability to affect...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34769066
DOI: 10.3390/ijms222111636
PMCID: PMC8583860

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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